The Ōtsutsuki Clan is an ancient clan of celestial beings, from which the Byakugan descends. After arriving from space in order to cultivate a Divine Tree on Earth, Kaguya Ōtsutsuki defected from the clan, resulting in the eventual lineage of the Uchiha, Senju, Uzumaki, and Hyuga clans. The status of the clan beyond Earth is unknown.
As a parasitic species they have spent thousands of years traversing the cosmos in order to carry out the Ōtsutsuki Will (大筒木の意志, Ōtsutsuki no Ishi), a doctrine which dictates that clan members consume the life energy and genetic material of other worlds in order to continuously evolve, with the ultimate goal of attaining godhood.
After the arrival of the clan's members on Earth a millennium ago, the Ōtsutsuki began having a lasting influence on the human population, notably starting the history of shinobi.
For countless eons, the Otsutsuki clan have been travelling throughout dimensions seeking out worlds to plant Ten-Tail saplings into. Once planted, it grows into a God Tree with its roots spreading across the planet to siphon chakra and genetic material from all its surroundings and inhabitants, resulting in everything dying and it bearing a large fruit for the Ōtsutsuki to consume in order for them to evolve, gaining power and longevity. Once harvested, as they no longer need the planet, they move to another to repeat the process. In order for the Ten-Tails seeds to bloom into a God Tree, a living Ōtsutsuki must be fed to the beast, hence the clan members travel in pairs, with the lower ranking being the sacrifice, while the other one watches over the fruit's cultivation. However, the Ōtsutsuki to be sacrificed utilize Kāma to prepare a vessel beforehand in order to revive themselves.
A millennium ago, the clan sent Kaguya and Isshiki to harvest the Earth's God Tree of its chakra fruit. Instead Kaguya developed an attachment for the planet she meant to destroy, betraying Isshiki in the process whom she left for dead. In desperation, Isshiki used his Sukunahikona to reduce his body's size and infiltrate the body of a monk named Jigen, taking him over through parasitic means. Meanwhile, Kaguya consumed the chakra fruit herself and used its godlike power to end the constant war of Earth's human population with the Infinite Tsukuyomi, resulting in world peace and her being initially viewed as a benevolent deity. Foreseeing the consequences of consuming the Chakra fruit against her clan's wishes, she converted the imprisoned Infinite Tsukuyomi victims into a White Zetsu Army in preparation for the arrival of other clansmen looking to steal her chakra — an act which lead to humans viewing her as a demon and the Ōtsutsuki condemning her as a traitor.
In time Kaguya gave birth to twin sons: Hagoromo and Hamura, both of whom were born with chakra of their own. Afterwards, Kaguya eventually found herself ruled by her own desire to possess all chakra, in which made her turn against her own sons. Having devised a plan to absorb their chakra, she integrated with the Earth's God Tree and became the Ten-Tails. The monster terrorized the world until Hagoromo and Hamura sealed it with their Six Paths — Chibaku Tensei, thus creating the Moon. The Ten-Tails' chakra was sealed into Hagoromo while its husk, the Demonic Statue of the Outer Path, was hidden away and sealed on the Moon, in order to prevent the Ten-Tails' revival. Before being sealed, Kaguya created a parasitic lifeform containing her will, Black Zetsu to find a way to revive her. Leaving leadership of the clan to Hamura, he decreed that the clan would stand guard over the Demonic Statue. Hagoromo and his brother's direct bloodline stayed on Earth, the latter which inherited the Byakugan and became the Hyūga clan, while Hamura migrated the clan to the moon, maintaining order and stability with the power of his Tenseigan.
Believing chakra was a power that linked everything in the world, Hagoromo set out to spread the message to the people of the land, during which his teachings became known as ninshū. Towards the end of his life, he divided his chakra into the nine tailed beasts, his way of ensuring that the Ten-Tails and thus Kaguya would never be reborn. Before he died, he passed over his eldest son, Indra, and entrusted his mission of peace to his youngest son, Asura. Black Zetsu manipulated Indra's jealousy toward Asura, resulting in the two brothers' confrontation being passed on to their descendants by the pair being reincarnated. Having spent the remainder of his life overlooking Earth, Hamura entrusted his Ōtsutsuki clansmen with a celestial degree watching over humanity before his passing. Afterwards, the people of the moon treated Hamura's Tenseigan as a treasure, enshrining it as a religious object and devoting a plan to eternally preserving it with the Byakugan of newborn members taken and put into the vessel to power it.
The millennium that passed involved the Moon's branch family misinterpreting Hamura's celestial decree, leading to them believing he wanted his descendants to destroy Earth in the event the world Hagoromo fashioned lead astray. The main family warred against the branch family over their different interpretations and eventually annihilated the former using the weaponized Tenseigan. On Earth, humans along with Ōtsutsuki's descendants such as the Senju, Uzumaki, Uchiha, Hyūga, and Kaguya clan utilized Indra's invention of ninjutsu to shape the shinobi world.
A thousand years after the Ten-Tails' defeat, the Moon's branch family dwindled to only Toneri, who was aware that the Demonic Statue was stolen and the Ten-Tails was revived during the Fourth Shinobi World War. The event ultimately lead to Kaguya being temporarily revived, but was soon sealed along with Black Zetsu in another dimension by the reincarnations of Asura and Indra. Two years later, as his clan had concluded that Earth's shinobi will destroy the world's peace and order, Toneri deemed Hagoromo's world a failure, and began to act on Hamura's mistranslated celestial decree. Unable to reach an agreement with the Hyūga clan, Toneri resorted to kidnapping the clan's heir and taking her Byakugan in order to awaken the Tenseigan. The act caught the attention of Konohagakure, leading to a team discovering his intentions and defeating him. After becoming aware of Hamura's true decree, he vowed to remain in self-imposed exile on the Moon in order to stand vigil over the Earth as a solitary guardian.
Years later during the Seventh Hokage's era, Momoshiki and Kinshiki in another world became aware of abnormalities in Kaguya's world, prompting them to inform their clan and investigate the situation. Though they weren't aware of the fate of Kaguya or her chakra, by Urashiki's account they saw everything including the Byakugan Princess incident on the Moon. They deemed Kaguya a disgrace and traitor for growing an attachment to Earth and taking up arms against them. By the time Momoshiki and Kinshiki were defeated, Konoha had discovered four separate Ōtsutsuki clan ruins during their investigation of the clan. Sometime afterwards, Konoha had discovered the clan's time-travelling artefact Karasuki, which Urashiki took in a final bid at stealing the Nine-Tails' chakra from the past, only for him to meet his end.
In the meanwhile, Jigen as Isshiki's vessel managed to acquire a juvenile Ten-Tails, planning to use it together with Kara as a seed for the new God Tree on Earth. Originally, Isshiki was planning to feed himself via Jigen to this Ten-Tails for it to bloom into the God Tree, due to Kaguya's betrayal and sealing leaving him with no other option, despite the resulting Chakra Fruit being much lower quality due to Isshiki's fatal injury; Kawaki was then to serve as the vessel for Isshiki's resurrection. There was some kind of time limit to their plans, but it was extended to an indefinite amount when Kara discovered that Momoshiki also created a vessel of his own, Boruto Uzumaki, before dying. Realizing Boruto will be revived as Momoshiki, Isshiki shifted his plans to using the boy instead of himself as a sacrifice for the Ten-Tails, which would produce a much more powerful God Tree and Chakra Fruit. Isshiki's plans ultimately ended in failure as he was betrayed by his subordinates Amado and Koji Kashin, and Kawaki freeing himself as the vessel, which led to Isshiki's demise. Momoshiki, having taken over much of Boruto's being, saw Isshiki's death as a benefit to him.
Despite Kawaki having lost the Kāma, he still had 80% of its biological data extracted into his body, causing Momoshiki to deem him close to a full Ōtsutsuki, and thus a viable sacrifice for the Ten-Tails. However, Boruto managed to regain control of his own body before Momoshiki could take Kawaki to the beast. Soon after, Isshiki's expiring soul appeared before his loyal servant and failed vessel, Code, and bade him use his White Kāma to transform into an Ōtsutsuki and carry on the Ōtsutsuki Will. Code agreed to do so after first getting revenge on those who killed his master.
The Ōtsutsuki clan is capable of implanting humans with a Karma seal which allows them to gradually override the host's consciousness and replace it with their own once the Ōtsutsuki dies.
- Isshiki Ōtsutsuki
- Kaguya Ōtsutsuki
- Momoshiki Ōtsutsuki
- Kinshiki Ōtsutsuki
- Urashiki Ōtsutsuki
- Hagoromo Ōtsutsuki
- Hamura Ōtsutsuki
- Toneri Ōtsutsuki